K-Ras ligand-Linker Conjugate 3 |
| Katalog-Nr.GC39190 |
K-Ras-Ligand-Linker-Konjugat 3 (Verbindung 001371) enthÄlt einen Liganden fÜr die rekrutierende Einheit von K-Ras und einen PROTAC-Linker, die E3-Ligasen (wie VHL, CRBN, MDM2 und IAP) rekrutieren. K-Ras-Ligand-Linker-Konjugat 3 kann bei der Synthese von PROTAC K-Ras Degrader-1 verwendet werden, einem potenten PROTAC K-Ras-Degrader, der eine Abbaueffizienz von ≥70 % in SW1573-Zellen aufweist.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2378261-87-9
Sample solution is provided at 25 µL, 10mM.
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K-Ras ligand-Linker Conjugate 3 (Compound 001371) incorporates a ligand for FAK (a KRas recruiting moiety), and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 3 can be extensively used for PROTAC-mediated protein degradation[1].
[1]. Andrew P. Crew, et al. Modulators of proteolysis and associated methods of use. WO2019195609A2.
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