KB02-JQ1 |
| Catalog No.GC60964 |
KB02-JQ1은 선택성이 높은 PROTAC 기반 BRD4 분해제(분자 접착제)이지만 BRD2 또는 BRD3을 분해하지 않습니다. KB02-JQ1은 DCAF16(E3 ligase)을 공유적으로 변형하여 BRD4 분해를 촉진하고 생물학적 시스템에서 단백질 분해의 내구성을 향상시킬 수 있습니다. JQ1은 링커를 통해 유비퀴틴 E3 리가제 리간드 KB02에 결합하여 KB02-JQ1을 형성합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2384184-44-3
Sample solution is provided at 25 µL, 10mM.
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KB02-JQ1 is a highly selective and PROTAC-based BRD4 degrader (molecular glue), but does not degrade BRD2 or BRD3. KB02-JQ1 promotes BRD4 degradation by covalently modifying DCAF16 (E3 ligase) and can improve the durability of protein degradation in biological systems. JQ1 binds ubiquitin E3 ligase ligand KB02 via a linker to form KB02-JQ1[1].
KB02-JQ1 (5-40 μM; 24 hours; HEK293T cells) treatment shows concentration-dependent degradation of endogenous BRD4 in HEK293T cells[1]. Western Blot Analysis[1] Cell Line: HEK293T cells
[1]. Zhang X, et al. Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16. Nat Chem Biol. 2019 Jul;15(7):737-746.
Average Rating: 5 (Based on Reviews and 21 reference(s) in Google Scholar.)
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