KEA1-97 |
| Catalog No.GC63031 |
KEA1-97은 선택적 티오레독신-카스파제 3 상호작용 교란물질(IC50=10μM)입니다. KEA1-97은 thioredoxin과 caspase 3의 상호작용을 방해하고 caspase를 활성화하며 thioredoxin 활성에 영향을 미치지 않으면서 세포자멸사를 유도합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2138882-71-8
Sample solution is provided at 25 µL, 10mM.
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KEA1-97 is a selective Thioredoxin-caspase 3 interaction disruptor (IC50=10 μM). KEA1-97 disrupts the interaction of thioredoxin with caspase 3, activates caspases, and induces apoptosis without affecting thioredoxin activity[1].
KEA1-97 (100 μM; 231MFP cells) impaires thioredoxin pulldown of caspase 3[1].KEA1-97 (10 μM; 48 hours; 231MFP cells) impaires 231MFP serum-free cell proliferation[1].KEA1-97 (10 μM; 0~12 hours; 231MFP cells) activates caspase 3/7 and induces apoptotic cell death[1].KEA1-97 (231MFP cells) resistants to survival and proliferation impairments[1].
KEA1-97 (5 mg/kg; i.p.; 50 days) attenuates tumor xenograft growth[1].
[1]. Anderson KE, et al. Chemoproteomics-Enabled Covalent Ligand Screening Reveals a Thioredoxin-Caspase 3 Interaction Disruptor That Impairs Breast Cancer Pathogenicity. ACS Chem Biol. 2017;12(10):2522-2528.
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