KHK-IN-1 (ketohexokinase inhibitor) |
| Catalog No.GC30367 |
KHK-IN-1(케토헥소키나제 억제제)은 IC50이 12nM인 강력한 케토헥소키나제(KHK) 억제제입니다. KHK의 ATP 결합 영역에서 Asp-27B와 상호 작용합니다.
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Cas No.: 1303469-70-6
Sample solution is provided at 25 µL, 10mM.
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KHK-IN-1 is a potent ketohexokinase (KHK) inhibitor with IC50 of 12 nM; interacts with Asp-27B in the ATP-binding region of KHK.
[1]. Maryanoff BE, et al. Pyrimidinopyrimidine inhibitors of ketohexokinase: exploring the ring C2 group that interacts with Asp-27B in the ligand binding pocket. Bioorg Med Chem Lett. 2012 Aug 15;22(16):5326-9. [2]. Maryanoff BE, et al. Inhibitors of Ketohexokinase: Discovery of Pyrimidinopyrimidines with Specific Substitution that Complements the ATP-Binding Site. ACS Med Chem Lett. 2011 Apr 18;2(7):538-43.
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