KSI-3716 |
| Catalog No.GC33377 |
KSI-3716은 c-MYC/MAX가 표적 유전자 프로모터에 결합하는 것을 차단하는 강력한 c-Myc 억제제입니다. KSI-3716은 방광암에 효과적인 방광내 화학요법제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1151813-61-4
Sample solution is provided at 25 µL, 10mM.
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KSI-3716 is a c-Myc inhibitor.
KSI-3716 blocks c-MYC/MAX from forming a complex with target gene promoters. KSI-3716 effectively blocks complex formation in a dose dependent manner (IC50=0.84 μM). c-MYC mediated transcriptional activity is inhibited by KSI-3716 at concentrations as low as 1 μM. The expression of c-MYC target genes, such as cyclin D2, CDK4 and hTERT, is markedly decreased. KSI-3716 exerts cytotoxic effects on bladder cancer cells by inducing cell cycle arrest and apoptosis[1].
Intravesical instillation of KSI-3716 at a dose of 5 mg/kg significantly suppresses tumor growth with minimal systemic toxicity[1].
[1]. Jeong KC, et al. Intravesical instillation of c-MYC inhibitor KSI-3716 suppresses orthotopic bladder tumor growth. J Urol. 2014 Feb;191(2):510-8.
Average Rating: 5 (Based on Reviews and 13 reference(s) in Google Scholar.)
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