LAMP1 Monoclonal Antibody (Clone Ly1C6) |
Catalog No.GC49471 |
For immunochemical analysis of LAMP1
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: N/A
Sample solution is provided at 25 µL, 10mM.
Lysosome associated membrane protein 1 (LAMP1) and LAMP2 are major constituents of the lysosomal membrane. The two have closely related structures, with 37% sequence homology.1 They are both transmembrane glycoproteins that are localized primarily in lysosomes and late endosomes. Newly synthesized molecules are mostly transported from the trans-
1.HÖning, S., Sandoval, I.V., and von Figura, K.A di-leucine-based motif in the cytoplasmic tail of LIMP-II and tyrosinase mediates selective binding of AP-3EMBO Journal17(5)1304-1314(1998) 2.Rohrer, J., Schweizer, A., Russel, D., et al.The targeting of lamp1 to lysosomes is dependent on the spacing of its cytoplasmic tail tyrosine sorting motif relative to the membraneJournal of Cell Biology132(4)565-576(1996) 3.GrÜtzkau, A., Smorodchenko, A., Lippert, U., et al.LAMP-1 and LAMP-2, but not LAMP-3, are reliable markers for activation-induced secretion of human mast cellsCytometry Part A61(1)62-68(2004) 4.Kannan, K., Stewart, R.M., Bounds, W., et al.Lysosome-associated membrane proteins h-LAMP1 (CD107a) and h-LAMP2 (CD107b) are activation-dependent cell surface glycoproteins in human peripheral blood mononuclear cells which mediate cell adhesion to vascular endotheliumCellular Immunology171(1)10-19(1996)
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