Mapracorat (Synonyms: ZK-245186; BOL-303242X) |
| Catalog No.GC19239 |
Mapracorat는 새로운 비스테로이드성 선택적 글루코코르티코이드 수용체 작용제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 887375-26-0
Sample solution is provided at 25 µL, 10mM.
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Mapracorat is a novel non-steroidal selective glucocorticoid receptor agonist.
Mapracorat concentration dependently inhibited TNFα secretion from activated canine PBMC with IC50 value of approximately 0.2 nM.
Intradermal injection of compound 48/80 (50 ug in 50 uL saline) resulted in a clear wheal and flare reaction over the 60 min observation period. Topical pre-treatment with mapracorat (0.1%) and triamcinolone acetonide (0.015%) led to significant reduction in the wheal and flare responses compared to vehicle (acetone) treated areas. However, once daily topical administration of triamcinolone acetonide significantly reduced skin fold thickness from day 8 to 14, whereas no such reduction was observed for mapracorat.
References:
[1]. Baumer W , et al. The selective glucocorticoid receptor agonist mapracorat displays a favourable safety-efficacy ratio for the topical treatment of inflammatory skin diseases in dogs. Vet Dermatol. 2017 Feb; 28(1):46-e11.
[2]. Baiula M, et al. Mapracorat, a novel non-steroidal selective glucocorticoid receptor agonist for the treatment of allergic conjunctivitis.Inflamm Allergy Drug Targets. 2014; 13(5):289-98.
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