>>Signaling Pathways>> Vitamin D Related>> VD/VDR>>Calcifediol-D6

Calcifediol-D6

Catalog No.GC35582

Calcifediol-d6은 Calcifediol이라고 표시된 중수소입니다.

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Calcifediol-D6 Chemical Structure

Cas No.: 78782-98-6

Size 가격 재고 수량
1mg
US$945.00
재고 있음
500ug
US$522.00
재고 있음

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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents Related Products

Calcifediol-D6 is the deuterated form of Calcifediol(25-hydroxy Vitamin D3), which is a prehormone that is produced in the liver by hydroxylation of vitamin D3 (cholecalciferol) by the enzyme cholecalciferol 25-hydroxylase IC50 value:Target: This metabolite is being measured by physicians worldwide to determine a patient's vitamin d status.Calcifediol is then converted in the kidneys (by the enzyme 25(OH)D-1α-hydroxylase) into calcitriol (1,25-(OH)2D3), a secosteroid hormone that is the active form of vitamin D. It can also be converted into 24-hydroxycalcidiol in the kidneys via 24-hydroxylation.

[1]. Teitelbaum SL. Calcifediol (25-hydroxyvitamin D3) in the treatment of uremic bone disease. Ann Intern Med. 1981 Mar;94(3):404-5. [2]. Kleinman LM, Letteri JM, Asad SN, Ellis KJ, Cohn SH. Effects of calcifediol on calcified tissue in uremia. Arch Intern Med. 1978 May 15;138 Spec No:864-5. [3]. Recker R, Schoenfeld P, Letteri J, Slatopolsky E, Goldsmith R, Brickman A. The efficacy of calcifediol in renal osteodystrophy. Arch Intern Med. 1978 May 15;138 Spec No:857-63. [4]. Teitelbaum SL, Bone JM, Stein PM, Gilden JJ, Bates M, Boisseau VC, Avioli LV. Calcifediol in chronic renal insufficiency. Skeletal response. JAMA. 1976 Jan 12;235(2):164-7.

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