Methoprene (ZR-515) |
Catalog No.GC32102
One-Click Copy Product Info
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Methoprene (ZR-515)은 유아 호르몬 유사물(JHA)에 속하는 성장 조절 살충제이다. 유아 호르몬의 효과를 모방하고 곤충의 정상적인 발육 주기를 방해해서 해충 개체 그룹의 성장을 억제한다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 40596-69-8
Sample solution is provided at 25 µL, 10mM.
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Methoprene (ZR-515)은 유아 호르몬 유사물(JHA)에 속하는 성장 조절 살충제이다. 유아 호르몬의 효과를 모방하고 곤충의 정상적인 발육 주기를 방해해서 해충 개체 그룹의 성장을 억제한다. Methoprene은 모기 유충(예: 아데스와 쿨렉스)을 제어하는데 널리 사용되고 성충으로의 발육을 차단해서 덴기열과 지카 바이러스와 같은 모기 매개 질병의 확산을 줄인다[2]. Methoprene은 모기 변태 과정에서 중장의 재구성을 방해할 수 있다[3]. Methoprene은 비표적 생물(예: 포유류와 새)에 대해 극도로 저독성이고 우수한 환경 안전성을 가지고 있고 통합 해충 관리(IPM) 시스템에 적합한다[4].
체외 실험에서 Methoprene(0-200μM)으로 Spodoptera frugiperda Sf9 세포 라인을 24-72시간 처리하면 세포 증식을 용량 및 시간 의존적으로 억제하고 세포 G2/M기 지연을 현저하게 유도했다[5].
체내 실험에서 Methoprene(2, 50, 200μg/L)으로 체리새우 Neocaridina Davidi를 처리하면 체장과 탈피 빈도를 감소시키고 외골격 발달과 탄수화물,펩타이드, 지질 대사를 교란했다[6].
References:
[1] Ramaseshadri P, Farkaš R, Palli S R. Recent progress in juvenile hormone analogs (JHA) research[J]. Advances in insect physiology, 2012, 43: 353-436.
[2] Cuervo-Parra J A, Cortés T R, Ramirez-Lepe M. Mosquito-borne diseases, pesticides used for mosquito control, and development of resistance to insecticides[J]. Insecticides resistance. Rijeka: InTechOpen, 2016, 2: 111-34.
[3] Nishiura J T, Ho P, Ray K. Methoprene interferes with mosquito midgut remodeling during metamorphosis[J]. Journal of medical entomology, 2003, 40(4): 498-507.
[4] Munjal K, Gauttam V K, Mir S R, et al. Insect Growth Regulators[M]//Biopesticides Handbook. CRC Press, 2023: 223-242.
[5] Giraudo M, Califano J, Hilliou F, et al. Effects of hormone agonists on Sf9 cells, proliferation and cell cycle arrest[J]. PLoS One, 2011, 6(10): e25708.
[6] Hu X L, Niu J J, Meng Q, et al. Effects of two juvenile hormone analogue insecticides, fenoxycarb and methoprene, on Neocaridina davidi[J]. Environmental Pollution, 2019, 253: 89-99.
| 세포 실험 [1]: | |
세포 라인 | Spodoptera frugiperda Sf9 세포 라인 |
제조 방법 | Sf9 세포를 0-200μM의 Methoprene으로 24, 48, 72시간 처리하고 MTT 실험으로 세포 생존율을 측정했습니다. |
반응 조건 | 0-200μM; 24, 48, 72시간 동안 |
응용 분야 | Methoprene은 용량 및 시간 의존적으로 세포 증식을 억제했습니다. |
References: | |
| Cas No. | 40596-69-8 | SDF | |
| Canonical SMILES | CC(C)(OC)CCCC(C)C/C=C/C(C)=C/C(OC(C)C)=O | ||
| Formula | C19H34O3 | M.Wt | 310.47 |
| Solubility | DMSO : ≥ 60 mg/mL (193.26 mM) | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.2209 mL | 16.1046 mL | 32.2092 mL |
| 5 mM | 644.2 μL | 3.2209 mL | 6.4418 mL |
| 10 mM | 322.1 μL | 1.6105 mL | 3.2209 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A liquid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 34 reference(s) in Google Scholar.)