PF 3084014 hydrobromide (Synonyms: PF-3084014 dihydrobromide; PF-03084014 dihydrobromide) |
| Catalog No.GC50251 |
PF 3084014 하이드로브로마이드(PF-3084014 디하이드로브로마이드)는 가역성, 경구 생체이용성, 비경쟁적 및 선택적 γ-세크레타제 억제제이며 IC50이 6.2nM입니다. 위장 독성을 최소화하면서 PF 3084014 하이드로브로마이드에 의한 Notch 신호전달의 억제는 Notch 수용체 의존성 암 연구를 위한 유망한 접근 방식을 제시합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1962925-29-6
Sample solution is provided at 25 µL, 10mM.
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Potent γ-secretase inhibitor (IC50 values are 1.2 and 6.2 nM in whole cell and cell-free assays, respectively). Reduces Aβ in brain, CSF and plasma in mice and guinea pigs.
Lanz et al (2010) Pharmacodynamics and pharmacokinetics of the gamma-secretase inhibitor PF-3084014. J.Pharmacol.Exp.Ther. 334 269 PMID:20363853
Average Rating: 5 (Based on Reviews and 39 reference(s) in Google Scholar.)
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