Mexiletine (hydrochloride) |
| Catalog No.GC44189 |
Mexiletine is a voltage-gated sodium channel blocker and class Ib antiarrhythmic agent that preferentially binds to open/inactive channels.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 5370-01-4
Sample solution is provided at 25 µL, 10mM.
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Mexiletine is a voltage-gated sodium channel blocker and class Ib antiarrhythmic agent that preferentially binds to open/inactive channels. It inhibits aconitine-induced dysrhythmias in mice with ED50 values of 57 and 107 mg/kg for intraperitoneal and oral administration, respectively. Mexiletine decreases or inhibits conduction across the Purkinje fiber-muscle junction, shortens action potential duration, and decreases the refractory period when used at concentrations less than 5 µg/ml in isolated canine Purkinje fiber and ventricular muscle preparations.
Average Rating: 5 (Based on Reviews and 20 reference(s) in Google Scholar.)
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