Mirtazapine D3 (Synonyms: 6-Azamianserin-d9, ORG 3770-d9) |
Catalog No.GC61067
One-Click Copy Product Info
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Mirtazapine D3(Org3770 D3; 6-Azamianserin D3)는 Mirtazapine으로 표시된 중수소입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1216678-68-0
Sample solution is provided at 25 µL, 10mM.
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Mirtazapine D3 (Org3770 D3; 6-Azamianserin D3) is a deuterium labeled Mirtazapine. Mirtazapine is a 5-HT receptor inhibitor. Mirtazapine is a potent and orally active noradrenergic and specific serotonergic antidepressant (NaSSA) agent by blocking 5-HT2 and 5-HT3 receptors[1].
Mirtazapine (intraperitoneal injection; 10-50 mg/Kg; 14 days) treatment normalizes heart rate, breath rate, anxiety levels and eliminates the hopping behavior observed in MeCP2-null mice, leading to improved phenotypic score[2]. Animal Model: MeCP2 null mice[2]
[1]. Anttila, S.A. and E.V. Leinonen, A review of the pharmacological and clinical profile of mirtazapine. CNS Drug Rev, 2001. 7(3): p. 249-64. [2]. Kooyman AR, et al. Interaction between enantiomers of mianserin and ORG3770 at 5-HT3 receptors in cultured mouse neuroblastoma cells.Neuropharmacology. 1994 Mar-Apr;33(3-4):501-7.
| Cas No. | 1216678-68-0 | SDF | |
| Synonyms | 6-Azamianserin-d9, ORG 3770-d9 | ||
| Canonical SMILES | [2H]C([2H])([2H])N1CC2C3=CC=CC=C3CC4=CC=CN=C4N2CC1 | ||
| Formula | C17H16D3N3 | M.Wt | 268.37 |
| Solubility | DMF: 20 mg/ml,DMF:PBS (pH 7.2) (1:5): 0.16 mg/ml,DMSO: 15 mg/ml,Ethanol: 15 mg/ml | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.7262 mL | 18.631 mL | 37.262 mL |
| 5 mM | 745.2 μL | 3.7262 mL | 7.4524 mL |
| 10 mM | 372.6 μL | 1.8631 mL | 3.7262 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 37 reference(s) in Google Scholar.)