MK-4101 |
Catalog No.GC13630 |
MK-4101은 Smoothened(SMO) 길항제(293개 세포의 경우 IC50 1.1μM)이자 고슴도치 경로의 강력한 억제제(마우스 세포의 경우 IC50 1.5μM, KYSE180 식도암 세포의 경우 IC50 1μM)입니다. MK-4101은 종양 세포 증식을 억제하고 광범위한 세포 사멸을 유도하는 강력한 항종양 활성을 가지고 있습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 935273-79-3
Sample solution is provided at 25 µL, 10mM.
IC50: 1.5 μmol/L for in mouse Light II cells by Gli_luc assay
MK-4101 is a Hedgehog (Hh) signaling pathway inhibitor.
Abnormal activation of the Hedgehog (Hh) signaling pathway is reported in the pathogenesis of various cancers, such as medulloblastoma and basal cell carcinoma.
In vitro: MK-4101 was found to target the Hh pathway in tumor cells, with the maximum inhibitory effect on Gli1. MK-4101 could also induce the deregulation of cell cycle and block of DNA replication in tumors. In addition, members of the IGF and Wnt signaling pathways were among the most highly deregulated genes by MK-4101, indicating that the interplay among Hh, IGF, and Wnt was critical in Hh-dependent tumorigenesis [1].
In vivo: In a previous study, using neonatally irradiated Ptch1(+/-) mice as a model of Hh-dependent tumors, the in vivo effects of MK-4101 was investigated for the treatment of medulloblastoma and basal cell carcinoma. Results showed a potent antitumor activity of MK-4101, achieved by the inhibition of proliferation and induction of extensive apoptosis. Moreover, beside antitumor activity on transplanted tumors, MK-4101 was found to be highly efficacious against primary medulloblastoma and basal cell carcinoma in the cerebellum and skin [1].
Clinical trial: Up to now, MK-4101 is still in the preclinical development stage.
Reference:
[1] Filocamo G et al. MK-4101, a Potent Inhibitor of the Hedgehog Pathway, Is Highly Active against Medulloblastoma and Basal Cell Carcinoma. Mol Cancer Ther. 2016 Jun;15(6):1177-89.
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