ML417 |
| Catalog No.GC39752 |
ML417은 EC50이 38nM인 선택적 뇌 침투 D3 도파민 수용체(D3R) 작용제입니다.
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Cas No.: 1386162-69-1
Sample solution is provided at 25 µL, 10mM.
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ML417 is a selective and brain penetrant D3 dopamine receptor (D3R) agonist, with an EC50 of 38 nM. ML417 potently promotes D3R-mediated β-arrestin translocation, G protein mediated signaling, and pERK phosphorylation with minimal effects on other GPCR-mediated signaling. ML417 exhibits neuroprotection against toxin-induced neurodegeneration of dopaminergic neurons[1].
[1]. Moritz AE, et al. Discovery, Optimization, and Characterization of ML417: A Novel and Highly Selective D3 Dopamine Receptor Agonist. J Med Chem. 2020;63(10):5526‐5567.
Average Rating: 5 (Based on Reviews and 17 reference(s) in Google Scholar.)
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