BC-DXI-843 |
| Catalog No.GC60625 |
BC-DXI-843은 0.92μM의 IC50, 루시퍼라제 분석에서 AIMP2(IC50 >100μM)에 비해 100배 이상의 선택성을 갖는 강력하고 특이적 AIMP2-DX2 억제제입니다. BC-DXI-843은 폐암에서 AIMP2-DX2를 표적으로 하는 유망한 리드로 작용합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2421117-98-6
Sample solution is provided at 25 µL, 10mM.
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BC-DXI-843 is a potent and specific AIMP2-DX2 inhibitor with an IC50 of 0.92 μM, more than 100-fold selectivity over AIMP2 (IC50 >100 μM) in a luciferase assay. BC-DXI-843 acts as a promising lead targeting AIMP2-DX2 in lung cancer[1].
BC-DXI-843 (0.0316-31.6 μM; 72 hours) suppresses cancer cell proliferation in a DX2-dependent manner. The EC50 in A549 cells is 1.20 μM, which is similar to the IC50 for inhibition of DX2. However, no inhibition of WI-26 cells is observed, suggesting that BC-DXI-843 specifically reduces the viability of cancer cells[1]. Cell Proliferation Assay[1] Cell Line: A549 cancer cells and WI-26 normal cells
BC-DXI-843 (50 mg/kg; intraperitoneally administered; every other day for 15 days) demonstrates in vivo efficacy in a tumor xenograft mouse model (H460 cells)[1]. Animal Model: 7-week-old female BALB/cSLC-nu/nu mice bearing H460 cells xenograft[1]
[1]. Aneesh Sivaraman, et al. Synthesis and Structure-Activity Relationships of Arylsulfonamides as AIMP2-DX2 Inhibitors for the Development of a Novel Anticancer Therapy. J Med Chem. 2020 May 28;63(10):5139-5158.
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