NB-360 |
Catalog No.GC65970
One-Click Copy Product Info
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NB-360은 강력하고 뇌를 관통할 수 있으며 경구로 생체 이용 가능한 이중 BACE1/BACE2 억제제입니다(IC50: 마우스 및 인간 BACE1=5 nM; BACE2=6 nM). 821d96072c2d58d8970e76f526b0f6b8NB-360은 우수한 약리학적 프로필과 아밀로이드-β의 강력한 감소를 보여줍니다. 821d96072c2d58d8970e76f526b0f6b8및 아밀로이드 전구체 단백질(APP) 형질전환 마우스의 신경염증. 821d96072c2d58d8970e76f526b0f6b8NB-360은 Aβ의 진행을 완전히 차단할 수 있습니다. 821d96072c2d58d8970e76f526b0f6b8APP 트랜스제닉 마우스의 뇌에 침착. 821d96072c2d58d8970e76f526b0f6b8NB-360은 관련 아스파르틸 프로테아제 펩신, 카텝신 D 및 카텝신 E에 대해 탁월한 선택성을 나타냅니다.821d96072c2d58d8970e76f526b0f6b8
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1262857-73-7
Sample solution is provided at 25 µL, 10mM.
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IC50: 5 nM (Mouse and human BACE1), 6 nM (BACE2)[1]
NB-360 is a potent, brain penetrable, and orally bioavailable dual BACE1/BACE2 inhibitor (IC50: mouse and human BACE1=5 nM; BACE2=6 nM). NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in amyloid precursor protein(APP) transgenic mice. NB-360 can completely block the progression of Aβ deposition in the brains of APP transgenic mice. NB-360 shows excellent selectivity over the related aspartyl proteases pepsin, cathepsin D and cathepsin E[1][2].
| Cas No. | 1262857-73-7 | SDF | |
| Formula | C21H19F4N5O2 | M.Wt | 449.4 |
| Solubility | DMSO : 250 mg/mL (556.30 mM; Need ultrasonic) | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.2252 mL | 11.1259 mL | 22.2519 mL |
| 5 mM | 445 μL | 2.2252 mL | 4.4504 mL |
| 10 mM | 222.5 μL | 1.1126 mL | 2.2252 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)