Necrosulfonamide-d4 (Synonyms: NSA-d4) |
Catalog No.GC49681 |
Necrosulfonamide-d4는 Necrosulfonamide로 표시된 중수소입니다. Necrosulfonamide는 MLKL(mixed lineage kinase domain-like protein)을 선택적으로 표적화하여 작용하는 괴사 억제제입니다. Necrosulfonamide는 MLKL-RIP1-RIP3 necrosome 복합체가 다운스트림 이펙터와 상호 작용하는 것을 방지합니다. MLKL은 괴사 유도 동안 RIP3의 중요한 기질입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1795144-22-7
Sample solution is provided at 25 µL, 10mM.
Necrosulfonamide-d4 is intended for use as an internal standard for the quantification of necrosulfonamide by GC- or LC-MS. Necrosulfonamide is an inhibitor of necroptosis, apoptosis, and pyroptosis.1,2 It inhibits IL-8-induced increases in receptor-interacting serine/threonine kinase 1 (RIPK1), RIPK3, mixed lineage kinase domain-like protein (MLKL), caspase-3, and caspase-8 levels, as well as IL-8-induced necroptosis and apoptosis in isolated human nucleus pulposus cells.1 Necrosulfonamide binds to gasdermin D and inhibits NLRP3- and pyrin-mediated pyroptosis in mouse bone marrow-derived macrophages (BMDMs) when used at a concentration of 5 µM.2 In vivo, necrosulfonamide (20 mg/kg) increases survival in a mouse model of LPS-induced sepsis. It also improves motor function and reduces spinal edema in a mouse model of surgically induced spinal cord injury (SCI).3
1.Zhang, Q.-X., Guo, D., Wang, F.-C., et al.Necrosulfonamide (NSA) protects intervertebral disc degeneration via necroptosis and apoptosis inhibitionEur. Rev. Med. Pharmacol. Sci.24(5)2683-2691(2020) 2.Rathkey, J.K., Zhao, J., Liu, Z., et al.Chemical disruption of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsisSci. Immunol.3(26)eaat2738(2018) 3.Jiao, J., Wang, Y., Ren, P., et al.Necrosulfonamide ameliorates neurological impairment in spinal cord injury by improving antioxidative capacityFront. Pharmacol.101538(2020)
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