Nitroflurbiprofen (HCT 1206) |
| Catalog No.GC34028 |
Nitroflurbiprofen(HCT 1206)은 산화질소(NO)를 제공하는 사이클로옥시게나제(COX) 억제제로 문맥 고혈압 간경변증 쥐에서 증가된 간내 혈관 긴장도를 조절합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 158836-71-6
Sample solution is provided at 25 µL, 10mM.
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Nitroflurbiprofen is a cyclooxygenase (COX) inhibitor with nitric oxide (NO)-donating properties, modulates the increased intrahepatic vascular tone in portal hypertensive cirrhotic rats.
In vivo hemodynamic measurements (n = 8/condition) and evaluation of the increased intrahepatic resistance by in situ perfusion (n=5/condition) are performed in rats with thioacetamide-induced cirrhosis that receive either Nitroflurbiprofen (45 mg/kg), Flurbiprofen (30 mg/kg, equimolar concentration to Nitroflurbiprofen), or vehicle by intraperitoneal injection 24 hours and 1 hour prior to the measurements. Treatment with Nitroflurbiprofen, an NO-releasing cyclooxygenase inhibitor, improves portal hypertension without major adverse effects in thioacetamide-induced cirrhotic rats by attenuating intrahepatic vascular resistance, endothelial dysfunction, and hepatic hyperreactivity to vasoconstrictors[1].
[1]. Laleman W, et al. Nitroflurbiprofen, a nitric oxide-releasing cyclooxygenase inhibitor, improves cirrhotic portalhypertension in rats. Gastroenterology. 2007 Feb;132(2):709-19.
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