ODN 2088 |
| Catalog No.GC66341 |
ODN 2088은 강력한 TLR3, TLR7 및 TLR9 억제제입니다. 821d96072c2d58d8970e76f526b0f6b8ODN 2088은 세포독성을 나타내지 않습니다. 821d96072c2d58d8970e76f526b0f6b8ODN 2088은 IFN-α의 방출을 억제합니다. 821d96072c2d58d8970e76f526b0f6b8및 IL-6.821d96072c2d58d8970e76f526b0f6b8
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1146541-45-8
Sample solution is provided at 25 µL, 10mM.
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ODN 2088 is a potent TLR3, TLR7 and TLR9 inhibitor. ODN 2088 shows no cytotoxic. ODN 2088 inhibits the release of IFN-α and IL-6[1][2][3].
ODN 2088 (0.01, 0.1, 1, 10 μM; 48 h) shows no cytotoxic for for human PBMCs[1].
ODN 2088 (0.01, 0.1, 1, 10 μM; 24 h) inhibits the release of IFN-α in CpG-ODN 2216 (3 μM) and TLR7-ligand RNA-ORN 22075 (5 μM) stimulated human PBMCs[1].
ODN 2088 (0.01, 0.1, 1, 10 μM; 48 h) hardly inhibits the IL-6 release stimulated with CpG-ODN 2006 (100 nM) but inhibits the IL-6 release stimulated with imiquimod (5 μg/ml) in human PBMCs[1].
ODN 2088 (0.1, 1, 10 μM; 24 h) hardly inhibits IL-6 release by B-cells stimulated with CpG-DNA 2006 (100 nM) but inhibits the IL-6 release by imiquimod (5 μg/ml) stimulated human B-cells[1].
ODN 2088 (1, 10 μM; 48 h) increases the expression of CD86 and HLA-DR in the absence of CpG-ODN 2006 or imiquimod in CD20+ B-cells[1].
ODN 2088 presumably impairs TLR9-induced signaling induces by CpG-ODNs by competitive binding to the C-terminal fragment of TLR9[1].
ODN 2088 (0.001, 0.01, 0.1, 1, 10 μM; 24 h) inhibits the TNF-α secretion in a dose-dependent manner in CpG-ODN 1826 (100 nM) stimulated BMDMs and shows weekly inhibits when stimulated by the TLR7-agonist imiquimod[3].
ODN 2088 (10 μM) stimulates B cells to proliferate[3].
Cell Cytotoxicity Assay[1]
| Cell Line: | Human PBMCs |
| Concentration: | 0.01, 0.1, 1, 10 μM |
| Incubation Time: | 48 h |
| Result: | Showed no cytotoxic for for human PBMCs. |
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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