p,p'-DDE (Synonyms: 4,4'-DDE, 4,4'-Dichlorodiphenyldichloroethylene, p,p'-Dichlorodiphenyldichloroethylene, NSC 1153) |
| Catalog No.GC44527 |
지속성 디클로로디페닐트리클로로에탄(DDT)의 주요 대사산물인 p,p'-DDE(4,4'-DDE)는 IC50이 5μM이고 Ki가 3.5μM인 강력한 안드로겐 수용체 길항제입니다.
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Cas No.: 72-55-9
Sample solution is provided at 25 µL, 10mM.
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p,p'-DDE is a metabolite and degradation product of the organochlorine pesticide DDT. It accumulates in smallmouth buffalo, channel catfish, and largemouth bass as well as sediment in the Huntsville Spring Branch-Indian Creek tributary system surrounding a DDT manufacturing plant where it is considered a persistent organic pollutant (POP). p,p'-DDE inhibits estrogen binding to rainbow trout estrogen receptors (rtERs) with an IC50 value of 8 µM. It induces concentration-dependent secretion of estradiol by granulosa and theca cell co-cultures isolated from porcine ovarian follicles. p,p'-DDE (50-100 µM) also decreases ATP levels, the proportion of sperm with high mitochondrial membrane potential, and motility of human sperm in vitro.
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