PCNA-I1 |
| Catalog No.GC44577 |
PCNA-I1은 강력한 PCNA(증식 세포 핵 항원) 억제제입니다. PCNA-I1은 0.41μM의 Kd로 PCNA 삼량체에 직접 결합하고 시험관내 및 생체내 모두에서 항종양 활성을 나타낸다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 444930-42-1
Sample solution is provided at 25 µL, 10mM.
PCNA-I1 is an inhibitor of proliferating cell nuclear antigen (PCNA) that binds to PCNA trimers (Kd = 0.41 µM) and dose-dependently reduces the level of PCNA associated with chromatin in PC3 cells. It preferentially inhibits growth of a variety of human and mouse cancer cell lines (IC50s = 0.05-0.3 µM) over non-transformed cells (IC50s = 0.99-2 µM). PCNA-I1 leads to an accumulation of cells in the G1 phase during the first 24 hours of incubation and halts the cell cycle in the S and G2/M phases by 72 hours following treatment. It also reduces tumor growth in an LNCaP prostate cancer mouse xenograft model when administered at a dose of 10 mg/kg, five days per week, for two weeks.
Average Rating: 5 (Based on Reviews and 9 reference(s) in Google Scholar.)
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