PDE12-IN-1 |
| Catalog No.GC63505 |
PDE12-IN-1은 효소 억제에 대한 pIC50 값이 9.1인 강력하고 선택적인 PDE12 억제제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2259620-80-7
Sample solution is provided at 25 µL, 10mM.
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PDE12-IN-1 is a potent and selective PDE12 inhibitor with a pIC50 value for enzyme inhibition of 9.1. PDE12-IN-1 increases 2′,5′-linked adenylate polymers (2-5A) levels, and the pEC50 value is 7.7. PDE12-IN-1 shows antiviral activity[1].
PDE12-IN-1 inhibits the EMCV-induced cytopathic effect in HeLa Ohio cells with a pIC50 of 6.7. PDE12-IN-1 inhibits HeLa Ohio cell proliferation in the absence of EMCV infection with a pIC50 of 5.7. PDE12-IN-1 inhibits the proliferation of both HeLa and HeLaδPDE12 cells with a pIC50 of 5.7. PDE12-IN-1 inhibits HRV infection with a pIC50 of 6.9[1].
[1]. Wood ER, et al. The Role of Phosphodiesterase 12 (PDE12) as a Negative Regulator of the Innate Immune Response and the Discovery of Antiviral Inhibitors. J Biol Chem. 2015 Aug 7;290(32):19681-96.
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