Physalin B |
| Catalog No.GC61183 |
케이프 구스베리의 주요 활성 스테로이드 성분 중 하나인 피살린 B는 p53 의존적 세포자멸사 경로를 조절하여 유방암 세포에서 세포 주기 정지를 유도하고 세포자멸사를 유발합니다. 피살린 B는 유비퀴틴-프로테아좀 경로를 억제하고 시험관 내에서 인간 결장암 세포에서 불완전한 자가포식 반응을 유도합니다.
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Cas No.: 23133-56-4
Sample solution is provided at 25 µL, 10mM.
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Physalin B, one of the major active steroidal constituents of Cape gooseberry, induces cell cycle arrest and triggers apoptosis in breast cancer cells through modulating p53-dependent apoptotic pathway. Physalin B inhibits the ubiquitin-proteasome pathway and induces incomplete autophagic response in human colon cancer cells in vitro[1][2].
[1]. Wang A, et al. Physalin B induces cell cycle arrest and triggers apoptosis in breast cancer cells through modulating p53-dependent apoptotic pathway. Biomed Pharmacother. 2018;101:334-341. [2]. Ma YM, et al. Physalin B not only inhibits the ubiquitin-proteasome pathway but also induces incomplete autophagic response in human colon cancer cells in vitro. Acta Pharmacol Sin. 2015;36(4):517-527.
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