PK-THPP |
| Catalog No.GC50147 |
Potent K2P9.1 (TASK-3) channel blocker
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1332454-07-5
Sample solution is provided at 25 µL, 10mM.
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Potent TASK-3 channel blocker (IC50 = 35 and 300 nM for TASK-3 and TASK-1 respectively). Increases breathing rate and induces respiratory alkalosis in rats.
Cotten (2013) TASK-1 (KCNK3) and TASK-3 (KCNK9) tandem pore potassium channel antagonists stimulate breathing in isoflurane-anesthetized rats. Anesth.Analg. 116 810 PMID:23460565 |Coburn et al (2012) Discovery of a pharmacologically active antagonist of the two-pore-domain potassium channel K2P9.1 (TASK-3). ChemMedChem 7 123 PMID:21916012
Average Rating: 5 (Based on Reviews and 15 reference(s) in Google Scholar.)
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