Pomalidomide-amido-C1-Br |
| Catalog No.GC39171 |
포말리도마이드-아미도-C1-Br은 포말리도마이드 기반 세레블론 리간드와 링커를 통합하는 합성된 E3 리가제 리간드-링커 접합체입니다. Pomalidomide-amido-C1-Br은 B-Raf PROTAC 분해기 PROTAC B-Raf 분해기 1을 설계하는 데 사용할 수 있습니다. PROTAC B-Raf 분해기 1은 항암 활성이 있습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2351106-38-0
Sample solution is provided at 25 µL, 10mM.
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Pomalidomide-amido-C1-Br is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker. Pomalidomide-amido-C1-Br can be used to design a B-Raf PROTAC degrader PROTAC B-Raf degrader 1. PROTAC B-Raf degrader 1 has anti-cancer activity[1].
[1]. Chen H, et al. Pomalidomide hybrids act as proteolysis targeting chimeras: Synthesis, anticancer activity and B-Raf degradation. Bioorg Chem. 2019 Jun;87:191-199.
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