Pomalidomide-amido-C1-Br |
| Katalog-Nr.GC39171 |
Pomalidomid-amido-C1-Br ist ein synthetisiertes E3-Ligase-Ligand-Linker-Konjugat, das den auf Pomalidomid basierenden Cereblon-Liganden und einen Linker enthÄlt. Pomalidomid-amido-C1-Br kann verwendet werden, um einen B-Raf-PROTAC-Degrader PROTAC B-Raf-Degrader 1 zu entwickeln. PROTAC B-Raf-Degrader 1 hat AntikrebsaktivitÄt.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2351106-38-0
Sample solution is provided at 25 µL, 10mM.
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Pomalidomide-amido-C1-Br is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker. Pomalidomide-amido-C1-Br can be used to design a B-Raf PROTAC degrader PROTAC B-Raf degrader 1. PROTAC B-Raf degrader 1 has anti-cancer activity[1].
[1]. Chen H, et al. Pomalidomide hybrids act as proteolysis targeting chimeras: Synthesis, anticancer activity and B-Raf degradation. Bioorg Chem. 2019 Jun;87:191-199.
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