QAQ dichloride |
| Catalog No.GC50174 |
광전환 가능한 전압 개폐형 Nav 및 Kv 채널 차단제인 QAQ 이염화물은 트랜스 형태(아조벤젠 광스위치의)에서는 채널을 차단하지만 시스 형태에서는 차단하지 않습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Photoswitchable Nav, Cav and Kv channel blocker. Blocks channels in the trans conformation. Switches conformation from cis to trans at 500 nm and trans to cis at 380 nm. Normally membrane impermeant, but enters nociceptive neurons via ion channels activated by noxious stimuli, particularly TRPV1. Exhibits optically reversible local anesthesia in rats.
Mourot et al (2012) Rapid optical control of nociception with an ion-channel photoswitch. Nat.Methods 9 396 PMID:22343342 |Banghart MR et al (2009) Photochromic blockers of voltage-gated potassium channels. Angew.Chem.Int.Ed. 48 9097 PMID:19882609
Average Rating: 5 (Based on Reviews and 17 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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