DPP-4
Dipeptidyl peptidase-4 (DPP-4), originally identified in 1966 as a dipeptide naphthylamidase hydrolyzing glycyl-prolyl-beta-naphthylamide, is a membrane-associated peptidase that selectively cleaves the N-terminal penultimate proline or alanine amino acids. The most common substrates of DPP-4 include glucagon-like peptide-1 (GLP-1), glucagon-like peptide-2 (GLP-2), peptide YY, neuropeptide, chemokine ligand 12/stromal-derived factor-1 (CXCL12/SDF-1) and substance P. DPP-4, as a type II cell surface protein and a soluble form, has been found to be widely distributed in organs (such as the bone marrow, the lung, spleen, liver, pancreas, kidney and intestines) and body fluids (such as serum/plasma, cerebrospinal fluid, synovial fluid and semen). Besides its peptidase activity, DPP-4 has been found to be associated with immune stimulation, extracellular matrix degradation, lipid accumulation and resistance to anticancer agents.
Products for DPP-4
- Cat.No. 상품명 정보
- GC15130 Alogliptin (SYR-322)
- GC13949 Alogliptin Benzoate A DPP-4 inhibitor
- GC12603 DPPI 1c hydrochloride A DPP-4 inhibitor
- GC10104 Glimepiride An antidiabetic sulfonylurea
- GC10802 K 579
- GC14827 Linagliptin (BI-1356) A potent DPP-4 inhibitor
- GC17012 MK3102 MK3102(MK-3102)는 강력하고 선택적이며 경구 활성이며 혈액뇌장벽인 DPP-4(dipeptidyl peptidase 4) 억제제를 통과합니다.
- GC14126 NVP DPP 728 dihydrochloride
- GC14786 P32/98 (hemifumarate) P32/98(헤미푸마레이트)은 130nM의 Ki 값을 갖는 디펩티딜 펩티다제 IV의 강력한 억제제입니다.
- GC14201 PK 44 phosphate DPP-IV inhibitor
- GC12895 Saxagliptin 삭사글립틴(BMS-477118)은 강력하고 선택적이고 가역적이며 경쟁적이며 경구 활성인 디펩티딜 펩티다제-4(DPP-4)(Ki = 0.6-1.3nM) 억제제입니다.
- GC12235 Sitagliptin (phosphate) 시타글립틴(인산염)(MK-0431 인산염)은 Caco-2 세포 추출물에서 IC50이 19nM인 DPP4의 강력한 억제제입니다.
- GC10298 Sitagliptin phosphate monohydrate
- GC10018 Talabostat mesylate 탈라보스타트 메실레이트(Val-boroPro 메실레이트, PT100 메실레이트)는 경구 활성 및 비선택적 디펩티딜 펩티다제 IV(DPP-IV) 억제제(IC50 < 4 nM, Ki = 0.18 nM)이자 섬유아세포 활성화 단백질(FAP)의 첫 번째 임상 억제제입니다. IC50 = 560 nM), DPP8/9(IC50 = 4/11 nM, Ki = 1.5/0.76 nM), 정지 세포 프롤린 디펩티다제(QPP)(IC50 = 310 nM), DPP2 및 기타 DASH 계열 효소를 억제합니다.
- GC15576 Teneligliptin hydrobromide A DPP-4 inhibitor
- GC16613 Trelagliptin A DDP-4 inhibitor
- GC17479 Trelagliptin succinate A DDP-4 inhibitor
- GC16733 Vildagliptin (LAF-237) A DPP-4 inhibitor