RG7713 (RO5028442) (Synonyms: RO5028442) |
| Catalog No.GC30890 |
RG7713(RO5028442)(RO5028442)은 Kis가 1nM(hV1a) 및 39nM(mV1a)인 매우 강력하고 선택적인 뇌 침투성 바소프레신 1a(V1a) 수용체 길항제입니다.
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Cas No.: 920022-47-5
Sample solution is provided at 25 µL, 10mM.
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RG7713 (RO5028442) is a highly potent and selective Brain-Penetrant Vasopressin 1a (V1a) receptor antagonist with Kis of 1 nM (hV1a) and 39 nM (mV1a).
RG7713 (RO5028442) (compound 8) has excellent binding in and functional affinity for hV1a, moderate mouse affinity, and excellent selectivity versus human V2 (hV2) and human oxytocin (hOT) receptors. RG7713 (RO5028442) shows high solubility. RG7713 (RO5028442) is found to be highly selective against a panel of 89 targets. Finally, RG7713 (RO5028442) is identified as a suitable compound for clinical studies[1].
[1]. Ratni H, et al. Discovery of highly selective brain-penetrant vasopressin 1a antagonists for the potential treatment of autism via a chemogenomic and scaffold hopping approach. J Med Chem. 2015 Mar 12;58(5):2275-89.
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