RI(dl)-2 TFA |
| Catalog No.GC61245 |
RI(dl)-2 TFA는 IC50이 11.1μM인 강력하고 선택적인 RAD51 매개 D-루프 형성 억제제입니다. RI(dl)-2 TFA는 ssDNA에 대한 RAD51 결합에 영향을 미치지 않으며 인간 세포에서 상동 재조합(HR) 활성을 억제합니다(3.0μM의 IC50).
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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RI(dl)-2 TFA is a potent and selective RAD51-mediated D-loop formation inhibitor with an IC50 of 11.1 μM. RI(dl)-2 TFA does not influence RAD51 binding to ssDNA and inhibits homologous recombination (HR) activity in human cells (IC50 of 3.0 μM)[1].
RI(dl)-2 stabilizes nucleoprotein filaments in a nonfunctional state, which are incapable of D-loop activity and simultaneously shielded from related (e.g., RAD52-mediated) pathways that promote single-strand annealing (SSA)[1].RI(dl)-2 does not modulate the affinity of RAD51 to ssDNA or the stability of preformed RAD51-ssDNA complexes when challenged with high concentrations of salt[1].
[1]. Wei Lv, et al. Development of Small Molecules that Specifically Inhibit the D-loop Activity of RAD51. J Med Chem. 2016 May 26;59(10):4511-25.
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