RI(dl)-2 TFA |
| Katalog-Nr.GC61245 |
RI(dl)-2 TFA ist ein potenter und selektiver RAD51-vermittelter Inhibitor der D-Loop-Bildung mit einem IC50 von 11,1 μM. RI(dl)-2 TFA beeinflusst nicht die Bindung von RAD51 an ssDNA und hemmt die AktivitÄt der homologen Rekombination (HR) in menschlichen Zellen (IC50 von 3,0 μM).
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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RI(dl)-2 TFA is a potent and selective RAD51-mediated D-loop formation inhibitor with an IC50 of 11.1 μM. RI(dl)-2 TFA does not influence RAD51 binding to ssDNA and inhibits homologous recombination (HR) activity in human cells (IC50 of 3.0 μM)[1].
RI(dl)-2 stabilizes nucleoprotein filaments in a nonfunctional state, which are incapable of D-loop activity and simultaneously shielded from related (e.g., RAD52-mediated) pathways that promote single-strand annealing (SSA)[1].RI(dl)-2 does not modulate the affinity of RAD51 to ssDNA or the stability of preformed RAD51-ssDNA complexes when challenged with high concentrations of salt[1].
[1]. Wei Lv, et al. Development of Small Molecules that Specifically Inhibit the D-loop Activity of RAD51. J Med Chem. 2016 May 26;59(10):4511-25.
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