(+/-) RK-682 (Synonyms: (±)-3-Hexadecanoyl-5-hydroxymethyltetronic acid) |
| Catalog No.GB40043 |
(±)-RK-682 (150627-37-5) is a protein tyrosine phosphatase inhibitor (IC50's = 54 7 µM for CD45, 2.0 μM for VHR; did not inhibit cdc25B) originally isolated from the fermentation of Streptomyces sp. 88-682. Inhibits cell cycle at G1/S. RK-682 has also been shown to inhibit PLA2 (IC50 = 16 μM), HIV-1 protease (IC50 = 84 μlM), and heparanase (IC50 = 17 μM). Natural RK-682 (R-isomer) and synthetic racemic material have identical phosphatase activity. Care should be taken when using RK-682 in the presence of metal salts - because it readily forms metal complexes that affects its phosphatase inhibitory activity. RK-682 has been identified as a potential promiscuous inhibitor.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 150627-37-5
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
(±)-RK-682 (150627-37-5) is a protein tyrosine phosphatase inhibitor (IC50's = 54 7 µM for CD45, 2.0 μM for VHR; did not inhibit cdc25B) originally isolated from the fermentation of Streptomyces sp. 88-682. Inhibits cell cycle at G1/S. RK-682 has also been shown to inhibit PLA2 (IC50 = 16 μM), HIV-1 protease (IC50 = 84 μlM), and heparanase (IC50 = 17 μM). Natural RK-682 (R-isomer) and synthetic racemic material have identical phosphatase activity. Care should be taken when using RK-682 in the presence of metal salts - because it readily forms metal complexes that affects its phosphatase inhibitory activity. RK-682 has been identified as a potential promiscuous inhibitor.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *