RRD-251 |
| Catalog No.GC62269 |
RRD-251은 강력한 항증식, 항혈관신생 및 항종양 활성과 함께 망막모세포종 종양 억제 단백질(Rb)-Raf-1 상호작용의 억제제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 72214-67-6
Sample solution is provided at 25 µL, 10mM.
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RRD-251 is an inhibitor of retinoblastoma tumor suppressor protein (Rb)-Raf-1 interaction, with potent anti-proliferative, anti-angiogenic and anti-tumor activities[1].
RRD-251 (10-50 μM; 24 hours) inhibits melanoma growth in-vitro[1].RRD-251 (50 μM; 2 hours) inhibits Rb-Raf-1 interaction and Rb phosphorylation in non-small cell lung cancer cells[1]. RRD-251 induces apoptosis (50 μM; 18 hours) and cell cycle arrest (20-50 μM; 4 hours)[1].RRD-251 alters the expression of cell cycle and apoptosis regulatory protein[1].
RRD-251 (50 mg/kg; i.p.; q.o.d; for 14 days) has anti-cancer activities in vivo on melanomas[1].
[1]. Sandeep Singh, et al. Rb-Raf-1 interaction disruptor RRD-251 induces apoptosis in metastatic melanoma cells and synergizes with dacarbazine. Mol Cancer Ther. 2010 Dec; 9(12): 3330-3341.
Average Rating: 5 (Based on Reviews and 24 reference(s) in Google Scholar.)
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