Sabatolimab (Synonyms: MBG453) |
| Catalog No.GC64424 |
사바톨리맙(MBG453)은 적응 및 선천 면역 반응을 조절하는 억제 수용체인 TIM-3을 표적으로 하는 고친화성 인간화 IgG4(S228P) 항체입니다.
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Cas No.: 2252262-24-9
Sample solution is provided at 25 µL, 10mM.
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Sabatolimab (MBG453) is a high-affinity, humanized, IgG4 (S228P) antibody targeting TIM-3, an inhibitory receptor that regulates adaptive and innate immune responses. Sabatolimab is a potential immunosuppression agent that can target TIM-3 on immune and myeloid cells[1].
[1]. Andrew M. Brunner, et al. Efficacy and Safety of Sabatolimab (MBG453) in Combination with Hypomethylating Agents (HMAs) in Patients with Acute Myeloid Leukemia (AML) and High-Risk Myelodysplastic Syndrome (HR-MDS): Updated Results from a Phase 1b Study. Blood (2020) 136 (Supplement 1): 1-2.
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