SCH 32615 |
| Catalog No.GC61457 |
SCH 32615는 엔케팔리나제(내인성 엔케팔린 분해를 담당하는 효소) 억제제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 83861-02-3
Sample solution is provided at 25 µL, 10mM.
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SCH 32615 is an enkephalinase (the enzymes responsible for the degradation of endogenous enkephalins) inhibitor. SCH 32615 can enhance surgery- and pregnancy-induced analgesia in mice[1][2].
SCH 32615 blocks the degradation of Met5-enkephalin by isolated enkephalinase, with the Ki of 19.5 nM[3].
SCH 32615 (150 mg/kg; s.c.) enhances surgery activated endogenous analgesia in mice[1].
[1]. Jayaram A, et, al. An enkephalinase inhibitor, SCH 32615, augments analgesia induced by surgery in mice. Anesthesiology. 1995 May;82(5):1283-7. [2]. Jayaram A, et, al. SCH 32615, an enkephalinase inhibitor, enhances pregnancy-induced analgesia in mice. Anesth Analg. 1995 May;80(5):944-8. [3]. Chipkin RE, et, al. Pharmacology of SCH 34826, an orally active enkephalinase inhibitor analgesic. J Pharmacol Exp Ther. 1988 Jun;245(3):829-38.
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