SIRT-IN-3 |
| Catalog No.GC61279 |
SIRT-IN-3은 SIRT1에 대한 IC50이 17μM인 강력한 SIRT 억제제입니다. SIRT-IN-3은 SIRT2 및 SIRT3에 비해 SIRT1에 대해 각각 약 4배 및 14배 선택성을 나타냅니다(각각 SIRT2 및 SIRT3에 대해 74μM 및 235μM의 IC50).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1211-19-4
Sample solution is provided at 25 µL, 10mM.
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SIRT-IN-3 is a potent SIRT inhibitor, with an IC50 of 17 μM for SIRT1. SIRT-IN-3 shows about 4-fold and 14-fold selectivity for SIRT1 over SIRT2 and SIRT3, respectively (IC50 of 74 μM and 235 μM for SIRT2 and SIRT3, respectively)[1].
SIRT-IN-3 (Compound 7) (30-300 μM; 8 hours) causes p53 acetylation in in HCT116 cells[1].
[1]. Suzuki T, et al. 2-Anilinobenzamides as SIRT inhibitors. ChemMedChem. 2006 Oct;1(10):1059-62.
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