SM-1295 |
| Catalog No.GC63194 |
SM-1295는 XIAP-BIR3, c-IAP1-BIR3 및 c-IAP2-BIR3에 대한 Kd 값이 각각 3077 nM, 3.2 nM 및 9.5 nM인 세포자멸 단백질(IAP) 길항제의 억제제입니다.
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Cas No.: 1562375-46-5
Sample solution is provided at 25 µL, 10mM.
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SM-1295 is an inhibitor of apoptosis protein (IAP) antagonist, with Kd values of 3077 nM, 3.2 nM and 9.5 nM for XIAP-BIR3, c-IAP1-BIR3 and c-IAP2-BIR3, respectively[1][2].
SM-1295 (compound 5) binds to both cIAP1 and cIAP2 proteins with Ki values of 900-fold for cIAP1 over XIAP[1].SM-1295 (compound 5) exhibits an IC50 of 46 nM in MDA-MB-231[1].
[1]. Haiying Sun, et al. Potent and Selective Small-Molecule Inhibitors of cIAP1/2 Proteins Reveal That the Binding of Smac Mimetics to XIAP BIR3 Is Not Required for Their Effective Induction of Cell Death in Tumor Cells. ACS Chem Biol. 2014 Apr 18;9(4):994-1002.
[2]. Hui Cong, et al. Inhibitor of Apoptosis Protein (IAP) Antagonists in Anticancer Agent Discovery: Current Status and Perspectives. J Med Chem. 2019 Jun 27;62(12):5750-5772.
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