Sulbutiamine (Bisibuthiamine) |
| Catalog No.GC31148 |
Sulbutiamine (Bisibuthiamine)은 무력증 치료에 사용되는 비타민 B1의 합성 유사체입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 3286-46-2
Sample solution is provided at 25 µL, 10mM.
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Sulbutiamine is a highly lipid soluble synthetic analogue of vitamin B1, used for the treatment of asthenia.
Sulbutiamine shows neuroprotective effects on hippocampal CA1 pyramidal neurons subjected to oxygen-glucose deprivation. Sulbutiamine enhances electrophysiological properties such as excitatory synaptic transmissions and intrinsic neuronal membrane input resistance in a concentration-dependent manner[1]. Sulbutiamine attenuates apoptotic cell death induced by serum deprivation and stimulates GSH and GST activity in a dose dependent manner. Furthermore, sulbutiamine decreases the expression of cleaved caspase-3 and AIF[2].
[1]. Kwag J, et al. Evidence for neuroprotective effect of sulbutiamine against oxygen-glucose deprivation in rat hippocampal CA1 pyramidal neurons. Biol Pharm Bull. 2011;34(11):1759-64. [2]. Kang KD, et al. Sulbutiamine counteracts trophic factor deprivation induced apoptotic cell death in transformed retinal ganglion cells. Neurochem Res. 2010 Nov;35(11):1828-39.
Average Rating: 5 (Based on Reviews and 34 reference(s) in Google Scholar.)
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