Sulbutiamine (Bisibuthiamine) |
| Katalog-Nr.GC31148 |
Sulbutiamin (Bisibuthiamin) ist ein synthetisches Analogon von Vitamin B1, das zur Behandlung von Asthenie verwendet wird.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 3286-46-2
Sample solution is provided at 25 µL, 10mM.
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Sulbutiamine is a highly lipid soluble synthetic analogue of vitamin B1, used for the treatment of asthenia.
Sulbutiamine shows neuroprotective effects on hippocampal CA1 pyramidal neurons subjected to oxygen-glucose deprivation. Sulbutiamine enhances electrophysiological properties such as excitatory synaptic transmissions and intrinsic neuronal membrane input resistance in a concentration-dependent manner[1]. Sulbutiamine attenuates apoptotic cell death induced by serum deprivation and stimulates GSH and GST activity in a dose dependent manner. Furthermore, sulbutiamine decreases the expression of cleaved caspase-3 and AIF[2].
[1]. Kwag J, et al. Evidence for neuroprotective effect of sulbutiamine against oxygen-glucose deprivation in rat hippocampal CA1 pyramidal neurons. Biol Pharm Bull. 2011;34(11):1759-64. [2]. Kang KD, et al. Sulbutiamine counteracts trophic factor deprivation induced apoptotic cell death in transformed retinal ganglion cells. Neurochem Res. 2010 Nov;35(11):1828-39.
Average Rating: 5 (Based on Reviews and 34 reference(s) in Google Scholar.)
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