TAK-615 |
| Catalog No.GC61313 |
TAK-615는 폐 섬유증 연구를 위한 LPA1 수용체의 음성 알로스테릭 조절제(NAM)입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1664335-55-0
Sample solution is provided at 25 µL, 10mM.
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TAK-615 is a negative allosteric modulator (NAM) of the LPA1 receptor for the research of pulmonary fibrosis. TAK-615 binds the LPA1 receptor with high affinity (Kd high affinity of 1.7 nM and Kd low affinity of 14.5 nM)[1].
TAK-615 partially inhibits the LPA response (60% at 10 µM, IC50 of 91±30 nM)[1].
[1]. Jonathan Ellery, et al. Identification of Compounds Acting as Negative Allosteric Modulators of the LPA 1 Receptor. Eur J Pharmacol. 2018 Aug 15;833:8-15.
Average Rating: 5 (Based on Reviews and 17 reference(s) in Google Scholar.)
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