Thymidine-d4 (Synonyms: dT-d4, 5-Methyldeoxyuridine-d4, Thymine deoxyriboside-d4, 2'-deoxy Thymidine-d4, 2'-deoxy-5-methyl-Uridine-d4) |
| Catalog No.GC49529 |
An internal standard for the quantification of thymidine
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 347841-67-2
Sample solution is provided at 25 µL, 10mM.
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Thymidine-d4 is intended for use as an internal standard for the quantification of thymidine by GC- or LC-MS. Thymidine is a pyrimidine nucleoside composed of a deoxyribose sugar and thymine base.1 It is phosphorylated by thymidine kinase 2 (TK2) in mitochondria to form deoxythymidine monophosphate .2 Oral administration of thymidine in combination with deoxycytidine increases lifespan in a Tk2 H126N knock-in mouse model of TK2 deficiency.
1.Berg, J.M., Tymoczko, J.L., and Stryer, L.Biochemistry(2002) 2.Lopez-Gomez, C., Levy, R.J., Sanchez-Quintero, M.J., et al.Deoxycytidine and deoxythymidine treatment for thymidine kinase 2 deficiencyAnn. Neurol.81(5)641-652(2017)
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