Tiazofurin (Synonyms: NSC 286193; Riboxamide) |
| Catalog No.GC67477 |
티아조푸린(NSC 286193)은 항종양 활성을 갖는 합성 뉴클레오사이드 유사체입니다. 821d96072c2d58d8970e76f526b0f6b8티아조푸린은 세포내에서 IMP 탈수소효소(IMPDH)의 강력한 억제제인 \u200b\u200b티아졸-4-카르복스아미드 아데닌 디뉴클레오티드(TAD)로 동화됩니다. 821d96072c2d58d8970e76f526b0f6b8티아조푸린은 또한 항오르토폭스바이러스 및 항바리올라 활성을 가지고 있습니다.821d96072c2d58d8970e76f526b0f6b8
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 60084-10-8
Sample solution is provided at 25 µL, 10mM.
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Tiazofurin (NSC 286193) is a synthetic nucleoside analogue with antineoplastic activity. Tiazofurin is anabolized intracellularly to tiazole-4-carboxamide adenine dinucleotide (TAD), a potent inhibitor of IMP dehydrogenase (IMPDH)[1]. Tiazofurin also has anti-orthopoxvirus and anti-variola activities[2].
[1]. Tricot G, Jayaram HN, Weber G, Hoffman R. Tiazofurin: biological effects and clinical uses. Int J Cell Cloning. 1990;8(3):161-170.
[2]. Robert O Baker, et al. Potential antiviral therapeutics for smallpox, monkeypox and other orthopoxvirus infections. Antiviral Res. 2003 Jan;57(1-2):13-23.
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