Tiazofurin (Synonyms: NSC 286193; Riboxamide) |
| Katalog-Nr.GC67477 |
Tiazofurin (NSC 286193) ist ein synthetisches Nukleosid-Analogon mit antineoplastischer Aktivität. Tiazofurin wird intrazellulär zu Tiazol-4-Carboxamid-Adenin-Dinukleotid (TAD), einem potenten Inhibitor der IMP-Dehydrogenase (IMPDH), anabolisiert. Tiazofurin hat auch Anti-Orthopoxvirus- und Anti-Variola-Aktivitäten.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 60084-10-8
Sample solution is provided at 25 µL, 10mM.
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Tiazofurin (NSC 286193) is a synthetic nucleoside analogue with antineoplastic activity. Tiazofurin is anabolized intracellularly to tiazole-4-carboxamide adenine dinucleotide (TAD), a potent inhibitor of IMP dehydrogenase (IMPDH)[1]. Tiazofurin also has anti-orthopoxvirus and anti-variola activities[2].
[1]. Tricot G, Jayaram HN, Weber G, Hoffman R. Tiazofurin: biological effects and clinical uses. Int J Cell Cloning. 1990;8(3):161-170.
[2]. Robert O Baker, et al. Potential antiviral therapeutics for smallpox, monkeypox and other orthopoxvirus infections. Antiviral Res. 2003 Jan;57(1-2):13-23.
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