UDP (sodium salt hydrate) (Synonyms: Uridine-5'-diphosphate) |
Catalog No.GC48987
One-Click Copy Product Info
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An agonist of P2Y6
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: N/A
Sample solution is provided at 25 µL, 10mM.
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UDP is the diphosphate of the nucleoside uridine. It is a specific agonist of the P2Y purinoceptor P2Y6 (EC50 = 13 nM for human P2Y6), stimulating the production of inflammatory mediators, phagocytosis, and vasoconstriction.1,2,3,4,5,6 UDP also acts as an antagonist of P2Y14, whose agonists include UDP-glucose , UDP-galactose, and UDP-glucuronic acid.1,2
1.Jacobson, K.A., Ivanov, A.A., de Castro, S., et al.Development of selective agonists and antagonists of P2Y receptorsPurinergic Signal.5(1)75-89(2009) 2.Abbracchio, M.P., Burnstock, G., Boeynaems, J.M., et al.International Union of Pharmacology LVIII: Update on the P2Y G protein-coupled nucleotide receptors: From molecular mechanisms and pathophysiology to therapyPharmacological Reviews58(3)281-341(2006) 3.Garcia, R.A., Yan, M., Search, D., et al.P2Y6 receptor potentiates pro-inflammatory responses in macrophages and exhibits differential roles in atherosclerotic lesion developmentPLoS One9(10)1-13(2014) 4.Inoue, K.UDP facilitates microglial phagocytosis through P2Y6 receptorsCell Adhesion & Migration1(3)131-132(2007) 5.Besada, P., Shin, D.H., Costanzi, S., et al.Structure-activity relationships of uridine 5’-diphosphate analogues at the human P2Y6 receptorJournal of Medicinal Chemistry49(18)5532-5543(2006) 6.Mitchell, C., Syed, N., Tengah, A., et al.Identification of contractile P2Y1, P2Y6, and P2Y12 receptors in rat intrapulmonary artery using selective ligandsJournal of Pharmacology and Experimental Therapeutics343(3)755-762(2012)
| Cas No. | N/A | SDF | |
| Synonyms | Uridine-5'-diphosphate | ||
| Canonical SMILES | OP(OP(OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C=CC(NC2=O)=O)O1)([O-])=O)([O-])=O.[Na+].[Na+].O | ||
| Formula | C9H12N2O12P2·2Na [XH2O] | M.Wt | 448.1 |
| Solubility | PBS (pH 7.2): 10 mg/ml | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.2316 mL | 11.1582 mL | 22.3164 mL |
| 5 mM | 446.3 μL | 2.2316 mL | 4.4633 mL |
| 10 mM | 223.2 μL | 1.1158 mL | 2.2316 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >95.00% Appearance: A crystalline solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 6 reference(s) in Google Scholar.)