Unoprostone isopropyl ester (Synonyms: 13,14dihydro15keto20ethyl Prostaglandin F2α isopropyl ester, Rescula) |
| Catalog No.GC45121 |
프로스타글란딘 대사 산물의 유사체인 Unoprostone isopropyl ester(Unoprostone isopropyl ester)는 강력한 큰 전도도 Ca2+-활성화된 K+(BK) 채널 활성화제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 120373-24-2
Sample solution is provided at 25 µL, 10mM.
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Unoprostone isopropyl ester (Rescula) is the clinically approved, prodrug form of unoprostone, which is a free acid analog of prostaglandin F2α (PGF2α). Both latanoprost and Rescula have been approved for the treatment of ocular hypertension. Both analogs of PGF2α are believed to act by increasing the rate of aqueous humor outflow through the uveoscleral pathway. Both drugs are believed to act as prodrugs, with endogenous esterases within the eye releasing the free acid active form of the drug. The typical does of Rescula (one drop of 0.12% solution) is nearly 100 times that of latanoprost. Rescula has very little activity on isolated DP or TP receptors, less than 0.0005% the activity of PGE2 on EP3 receptors, and about 3% of the activity of PGF2α on FP receptors.
Average Rating: 5 (Based on Reviews and 19 reference(s) in Google Scholar.)
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