Vasonatrin Peptide (1-27) (Synonyms: H2N-Gly-Leu-Ser-Lys-Gly-Cys-Phe-Gly-Leu-Lys-Leu-Asp-Arg-Ile-Gly-Ser-Met-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-OH ) |
Catalog No.GP10091 |
Vasonatrin Peptide (1-27), (C124H198N36O36S3), a peptide with the sequence H2N-GLSKGCFGLKLDRIGSMSGLGCNSFRY-OH, MW= 2865.4.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
vasonatrin peptide (VNP). VNP is a chimera of atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP).Atrial natriuretic peptide (ANP) is a 28-amino acid peptide that contains a 17-amino acid ring structure and is secreted from atrial myocytes. ANP possesses natriuretic and vasoactive actions and is important in the control of cardiorenal homeostasis (1). ANP mediates its biological actions via a specific ANP receptor (ANPR-A) that is expressed in endothelial cells and in renal epithelial cells (2). C-type natriuretic peptide (CNP) is a newly identified 22-amino acid peptide that like ANP has a 17-amino acid ring formed by a disulfide bond but is genetically distinct. Unlike ANP, CNP lacks the COOH-terminal amino acid extension from the ring structure. CNP functions biologically via a separate receptor (ANPR-B)that is expressed in vascular smooth muscle cells and in the kidney. While ANP and CNP both decrease cardiac preload and arterial pressure, they may involve different mechanisms (3).
Figure1 Formula of Vasonatrin Peptide (1-27),
Figure2 the structures of ANP, CNP, VNP, AC-NP
Ref:
1. De Bold, A. J., H. B. Borenstein, A. T. Veress, and H. Sonnenberg. 1981. A
rapid and potent natriuretic response to intravenous injection of atrial myocardial extracts in rats. Life Sci. 28:89-94.
2. Wilcox, J. N., A. Augustine, D. V. Goeddel, and D. G. Lowe. 1991. Differential regional expression of three natriuretic peptide receptor genes within primate tissues. Mol. Cell. Biol. 11:3454-3462.
3. Clavell, A. L., A. J. Stingo, C. M. Wei, D. M. Heublein, and J. C. Burnett,
Jr. 1993. C-type natriuretic peptide: a selective cardiovascular peptide. Am. J.Physiol. 264:R290-R295.
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