Vodobatinib (Synonyms: K0706) |
| Catalog No.GC62103 |
Vodobatinib(K0706)은 IC50이 7nM인 강력한 3세대 경구 활성 Bcr-Abl1 티로신 키나제 억제제입니다. Vodobatinib은 대부분의 BCR-ABL1 점 돌연변이에 대해 활성을 나타내며 BCR-ABL1T315I에 대해서는 활성이 없습니다. Vodobatinib은 만성 골수성 백혈병(CML) 연구에 사용할 수 있습니다.
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Cas No.: 1388803-90-4
Sample solution is provided at 25 µL, 10mM.
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Vodobatinib (K0706) is a potent, third generation and orally active Bcr-Abl1 tyrosine kinase inhibitor with an IC50 of 7 nM. Vodobatinib exhibits activity against most BCR-ABL1 point mutants, and has no activity against BCR-ABL1T315I. Vodobatinib can be used for chronic myeloid leukemia (CML) research[1][2].
In Ba/F3 cells expressing BCR-ABL1, BCR-ABL1L248V, BCR-ABL1Y253H, or BCR-ABL1E255V, Vodobatinib (K0706; 0-2000 nM) treatment shows potent inhibition of BCR-ABL1 tyrosine autophosphorylation[1].
[1]. Orlando Antelope, et al. BCR-ABL1 tyrosine kinase inhibitor K0706 exhibits preclinical activity in Philadelphia chromosome-positive leukemia. Exp Hematol. 2019 Sep;77:36-40.e2.
[2]. Phase 1 Trial of Vodobatinib, a Novel Oral BCR-ABL1 Tyrosine Kinase Inhibitor (TKI): Activity in CML Chronic Phase Patients Failing TKI Therapies Including Ponatinib. Session: 632: Chronic Myeloid Leukemia: Therapy: CML: New and Beyond.
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