Vodobatinib (Synonyms: K0706) |
| カタログ番号GC62103 |
ボドバチニブ (K0706) は、7 nM の IC50 を持つ強力な第 3 世代の経口活性 Bcr-Abl1 チロシンキナーゼ阻害剤です。ボドバチニブは、ほとんどの BCR-ABL1 点変異体に対して活性を示し、BCR-ABL1T315I に対しては活性を示しません。ボドバチニブは、慢性骨髄性白血病 (CML) の研究に使用できます。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1388803-90-4
Sample solution is provided at 25 µL, 10mM.
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Vodobatinib (K0706) is a potent, third generation and orally active Bcr-Abl1 tyrosine kinase inhibitor with an IC50 of 7 nM. Vodobatinib exhibits activity against most BCR-ABL1 point mutants, and has no activity against BCR-ABL1T315I. Vodobatinib can be used for chronic myeloid leukemia (CML) research[1][2].
In Ba/F3 cells expressing BCR-ABL1, BCR-ABL1L248V, BCR-ABL1Y253H, or BCR-ABL1E255V, Vodobatinib (K0706; 0-2000 nM) treatment shows potent inhibition of BCR-ABL1 tyrosine autophosphorylation[1].
[1]. Orlando Antelope, et al. BCR-ABL1 tyrosine kinase inhibitor K0706 exhibits preclinical activity in Philadelphia chromosome-positive leukemia. Exp Hematol. 2019 Sep;77:36-40.e2.
[2]. Phase 1 Trial of Vodobatinib, a Novel Oral BCR-ABL1 Tyrosine Kinase Inhibitor (TKI): Activity in CML Chronic Phase Patients Failing TKI Therapies Including Ponatinib. Session: 632: Chronic Myeloid Leukemia: Therapy: CML: New and Beyond.
Average Rating: 5 (Based on Reviews and 12 reference(s) in Google Scholar.)
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