VU 6001966 |
| Catalog No.GC50612 |
VU 6001966(화합물 15m)은 강력하고 mGlu2 및 mGlu3에 대해 각각 IC50이 78nM 및 \u003e30μM인 혈액-뇌 장벽 mGlu2(대사성 글루타메이트 수용체 2) 음성 알로스테릭 조절제를 통과합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2009052-76-8
Sample solution is provided at 25 µL, 10mM.
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Potent and selective mGlu2 negative allosteric modulator (IC50 = 78 nM). Exhibits > 350-fold selectivity for mGlu2 over mGlu3. Also exhibits selectivity over other mGluRs and a panel of GPCRs, ion channels and transporters. CNS penetrant.
Bollinger et al (2017) Design and synthesis of mGlu2 NAMs with improved potency and CNS penetration based on a truncated picolinamide core. ACS Med.Chem.Lett. 8 919 PMID:28947937
Average Rating: 5 (Based on Reviews and 15 reference(s) in Google Scholar.)
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