YAP-TEAD-IN-1 TFA |
| Catalog No.GC39461 |
YAP-TEAD-IN-1 TFA는 YAP-TEAD 상호작용의 강력하고 경쟁력 있는 펩티드 억제제입니다(IC50=25nM). YAP-TEAD-IN-1 TFA는 17mer 펩타이드이며 YAP(50-171)(Kd=40nM)보다 TEAD1(Kd=15nM)에 대한 결합 친화도가 더 높습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1659305-79-9
Sample solution is provided at 25 µL, 10mM.
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YAP-TEAD TFA is a potent and competitive peptide inhibitor of YAP-TEAD interaction (IC50=25 nM). YAP-TEAD TFA is a 17mer peptide and shows a higher the binding affinity to TEAD1 (Kd=15 nM) than YAP (50-171) (Kd= 40 nM)[1].
[1]. Zhang Z, et al. Structure-Based Design and Synthesis of Potent Cyclic Peptides Inhibiting the YAP-TEAD Protein-Protein Interaction.ACS Med Chem Lett. 2014 Jul 14;5(9):993-8.
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